Challenges and Promises of Pharmacogenetics in Cancer Therapeutics
نویسنده
چکیده
Genetic constitution represents an important cause for individual variations in the response and tolerance to drug treatment. Th ese variations are due to the germline mutations in genes that encode for drug-metabolizing enzymes, transporters, cellular targets and signaling pathways. Th e identifi cation of genetic variations that predict for drug response is an important step towards the translation of pharmacogenetics into clinical practice. Th e knowledge of pharmacogenetics can aid in the discovery, development and individualization of anticancer drugs.
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